What is the recommended acetaminophen dosing after endodontic treatment?

• A. 1000 mg every 4-6 hours postop
• B. 500 mg every 6 hours
• C. 650 mg every 4 hours
• D. 1000 mg every 8 hours

Answer: (A)

Managing pain after endodontic treatment relies on keeping acetaminophen at a therapeutic level while staying within safety limits. A common and effective approach is 1000 mg every 4 to 6 hours as needed, with a maximum of 4000 mg in 24 hours. This dosing provides a strong enough per-dose effect to control moderate post-op pain and maintains relief by not spacing doses too far apart. Waiting 8 hours between doses can leave gaps where pain flares, while smaller doses or unusual intervals may be less reliable for complete analgesia. So, the best option aligns with a 1000 mg per-dose schedule every 4–6 hours postoperatively.