In which scenarios are antibiotics indicated in endodontics?

• A. Prophylaxis for all endodontic procedures.
• B. Localized pain without swelling.
• C. Routine post-operative soreness.
• D. In spreading infections with systemic signs (fever, malaise, lymphadenopathy), facial space infection, focal swelling with systemic involvement, or cellulitis requiring systemic therapy.

Answer: (D)